Polymeric nanoparticles are one of the most studied strategies in modern medicine for drug encapsulation. The researchers' main interest is a formulation capable of administering the medication in a controlled mode and specific site. In this context, stimulus-responsive nanoparticles are highlighted, as these systems can have long circulation times, achieve the disease site, and improve intracellular medication administration. Therefore, this review addressed trends in drug delivery mechanisms and the influence of internal and external stimulus sources on the stimulus-responsive nanocarriers. Moreover, conventional and emerging methods for the synthesis of polymeric nanoparticles were reviewed.

聚合纳米颗粒是现代医学中用于药物包封的研究最多的策略之一。研究人员的主要兴趣是能够以受控模式和特定部位施用药物的制剂。在这种情况下，强调了刺激反应性纳米颗粒，因为这些系统可具有较长的循环时间，达到疾病部位并改善细胞内药物的给药。因此，本综述探讨了药物递送机制的趋势以及内部和外部刺激源对刺激响应性纳米载体的影响。此外，综述了用于合成聚合物纳米颗粒的常规方法和新兴方法。