ABSTRACT

A facile one-pot protocol for the synthesis of 2-amino-3-cyanopyridins using SBA-15@Triazine/H₅PW₁₀V₂O₄₀ as an efficient catalyst under ultrasonic conditions has been developed. The nanohybrid catalyst was prepared by the chemical anchoring of Keggin heteropolyacid H₅PW₁₀V₂O₄₀ onto the surface of SBA-15 mesoporous silica modified with 2-APTS -4,6-bis(3,5-dimethyl-1H-pyrazol- 1-yl)-1,3,5-triazine (ADMPT) linker. Then the nanohybrid was used as a green, efficient, eco-friendly, and highly recyclable catalyst for the one-pot and multi-component synthesis of 2-amino-3-cyanopyridin derivatives from the reaction of aldehydes, malononitrile, cyclic ketones and ammonium acetate under ultrasound waves with good to excellent yields (79–95%) and in a short span of time. This nanocatalyst was characterized by using FT-IR, XRD, SEM, TEM, BET, and EDX techniques.

摘要

已开发了一种简便的一锅操作规程，可在超声条件下使用SBA-15 @ Triazine / H ₅ PW ₁₀ V ₂ O ₄₀作为有效催化剂来合成2-氨基-3-氰基吡啶。通过Keggin杂多酸H ₅ PW ₁₀ V ₂ O ₄₀的化学锚固来制备纳米杂化催化剂。用2-APTS -4,6-双（3,5-二甲基-1H-吡唑-1-基）-1,3,5-三嗪（ADMPT）接头修饰的SBA-15中孔二氧化硅表面上。然后，该纳米杂化物被用作一种绿色，高效，环保且高度可回收的催化剂，用于通过醛，丙二腈，环酮和铵的反应一锅多组分合成2-氨基-3-氰基吡啶衍生物。超声波在短时间内可产生良好至极佳的收率（79–95％）。通过使用FT-IR，XRD，SEM，TEM，BET和EDX技术对这种纳米催化剂进行了表征。