Abstract

A new α-pyrone derivative, with a rare substitution pattern, was isolated from the solid rice media of the fungal endophyte Aspergillus versicolor associated with the fruit of the mangrove Avicennia marina. It was named allantopyrone E, after allantopyrones C and D. The aforementioned three are the only diaryl-substituted α-pyrones to be reported from nature. The unique structure was elucidated based on one- and two dimensional NMR data as well as high resolution mass spectroscopy. A biosynthetic scheme was proposed for the new compound. Furthermore, allantopyrone E showed cytotoxic effect on HeLa cells with IC₅₀= 50.97 μM.

摘要

从与红树林Avicennia marina果实相关的真菌内生菌杂色曲霉的固体稻米培养基中分离出一种新的具有罕见取代模式的α-吡喃酮衍生物。在尿囊素 C 和 D 之后，它被命名为尿囊素 E。上述三种是自然界中唯一报道的二芳基取代的α-吡喃酮。基于一维和二维核磁共振数据以及高分辨率质谱，阐明了独特的结构。提出了新化合物的生物合成方案。此外，尿囊素 E 对 HeLa 细胞具有细胞毒作用，IC ₅₀ = 50.97 μM。