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Fusapyrone A, a γ-pyrone derived from a desert Fusarium sp.
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2020-08-07 , DOI: 10.1080/10286020.2020.1794857
Xin Zhen 1 , Meng-Jia Mao 1, 2 , Ren-Zhong Wang 1 , Shan-Shan Chang 1 , Tong-Mei Xiao 1 , Ye-Xiang Wu 1 , Li-Yan Yu 1 , Ya-Li Song 2 , Ming-Hua Chen 1, 3 , Shu-Yi Si 1
Affiliation  

Abstract

In this work, we isolated and characterized fusapyrone A (1), a new γ-pyrone derivative, along with six previously described compounds from the rice fermentation of Fusarium sp. CPCC 401218, a fungus collected from the desert. The structure of 1 was characterized using various spectroscopic analyses, such as MS, IR, 1D, and 2D NMR. The absolute configuration of 1 was determined through the use of 13C NMR chemical shifts, electronic circular dichroism (ECD) and optical rotation (OR) calculations. Compound 1 was found to have weak antiproliferative activity for Hela cells, with an IC50 of 50.6 μM.



中文翻译:

Fusapyrone A,一种来自沙漠镰刀菌属(Fusarium sp。)的γ-吡喃酮。

摘要

在这项工作中,我们从镰孢镰刀菌(Fusarium sp。)的水稻发酵中分离并鉴定了一种新的γ-吡喃酮衍生物fusapyrone A(1),以及六种先前描述的化合物。CPCC 401218,一种从沙漠收集的真菌。使用各种光谱分析(例如MS,IR,1D和2D NMR)对1的结构进行了表征。通过使用13 C NMR化学位移,电子圆二色性(ECD)和旋光性(OR)计算来确定1的绝对构型。发现化合物1对Hela细胞具有较弱的抗增殖活性,IC 50为50.6μM。

更新日期:2020-08-07
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