Abstract

In this work, we isolated and characterized fusapyrone A (1), a new γ-pyrone derivative, along with six previously described compounds from the rice fermentation of Fusarium sp. CPCC 401218, a fungus collected from the desert. The structure of 1 was characterized using various spectroscopic analyses, such as MS, IR, 1D, and 2D NMR. The absolute configuration of 1 was determined through the use of ¹³C NMR chemical shifts, electronic circular dichroism (ECD) and optical rotation (OR) calculations. Compound 1 was found to have weak antiproliferative activity for Hela cells, with an IC₅₀ of 50.6 μM.

中文翻译：

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Fusapyrone A，一种来自沙漠镰刀菌属（Fusarium sp。）的γ-吡喃酮。

摘要

在这项工作中，我们从镰孢镰刀菌（Fusarium sp。）的水稻发酵中分离并鉴定了一种新的γ-吡喃酮衍生物fusapyrone A（1），以及六种先前描述的化合物。CPCC 401218，一种从沙漠收集的真菌。使用各种光谱分析（例如MS，IR，1D和2D NMR）对1的结构进行了表征。通过使用¹³ C NMR化学位移，电子圆二色性（ECD）和旋光性（OR）计算来确定1的绝对构型。发现化合物1对Hela细胞具有较弱的抗增殖活性，IC ₅₀为50.6μM。