Microbial conversion of lignocellulosic substrates to fuel and platform chemical intermediates offers a sustainable route to establish a viable bioeconomy. However, such approaches face a series of key technical, economic, and sustainability hurdles, including: incomplete substrate utilization, lignocellulosic hydrolysate, and/or end-product toxicity, inefficient product recovery, incompatible cultivation requirements, and insufficient productivity metrics. Development of a production host with native traits suitable for high productivity conversion of lignocellulosic substrates under process-relevant conditions offers a means to bypass the above-described hurdles and accelerate the development of microbial biocatalyst deployment. Clostridium tyrobutyricum, a native producer of short chain fatty acids, displays a series of characteristics that make it an ideal candidate for conversion of lignocellulosic substrates and thus represents a promising host for microbial production of diverse carboxylate-derived product suites. Herein, recent progress and future directions in the development of this bacterium as an industrial microbial cell factory, with emphases on the utilization of lignocellulosic substrates and metabolic engineering approaches, is reviewed.

木质纤维素底物的微生物转化为燃料和平台化学中间体提供了建立可行的生物经济的可持续途径。但是，这些方法面临一系列关键的技术，经济和可持续性障碍，包括：底物利用率不完全，木质纤维素水解产物和/或最终产品毒性，产品回收效率低下，不符合栽培要求以及生产率指标不足。具有适合在工艺相关条件下木质纤维素底物的高生产率转化的天然性状的生产宿主的开发提供了绕过上述障碍并加速微生物生物催化剂部署发展的手段。酪丁酸梭菌，是短链脂肪酸的天然生产商，具有一系列特性，使其成为木质纤维素底物转化的理想候选者，因此代表了微生物生产各种羧酸盐衍生产品套件的有希望的宿主。在此，综述了该细菌作为工业微生物细胞工厂的发展的最新进展和未来方向，重点是木质纤维素底物的利用和代谢工程方法。