Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediate the membrane contact between mitochondria and other organelles, and their functions, have been revealed in recent years. In this review article, we aim to summarize the findings on the tethering between mitochondria and other organelles in physiological or pathological conditions, and discuss their roles in cellular homeostasis, neural activity, and neurodegenerative diseases.

膜系留是膜包装细胞器的一种重要交流方法。线粒体是具有双层膜的细胞器，线粒体与其他细胞器之间的膜接触对于维持细胞稳态是必不可少的。近年来，已发现介导线粒体和其他细胞器之间的膜接触及其分子功能的分子决定簇水平增加。在这篇综述文章中，我们旨在总结有关线粒体和其他细胞器在生理或病理条件下系留的发现，并讨论它们在细胞稳态，神经活动和神经退行性疾病中的作用。