Background: This study was planned to investigate the association betweenhuman cytomegalovirus (HCMV) infection and gastrointestinal cancer (GIC) risk, by undertaking a meta-analysis and case-control cross-sectional study. Summary: A cross-sectional study analysis of 160 GIC patients and 100 control subjects indicated significantly higher HCMV prevalence in GIC patients based on the HCMV IgM test. However, a similar analysis based on an IgG test revealed no significant relationship. Further meta-analysis of 11 studies, including 1,044 patients and 991 healthy subjects, displayed HCMV infection as an important risk factor for not only colorectal cancer occurrence and development based on a HCMV DNA test, but also for GIC based on a HCMV IgM test. However, the IgG test again displayed no significant relationship between HCMV infection and GIC occurrence. Key Message: Overall, our study revealed that HCMV infection is associated with an increased GIC risk. However, additional studies are warranted to elucidate the molecular mechanism underlying this association.
Intervirology

中文翻译：

---

巨细胞病毒感染是胃肠道癌症的危险因素：一项跨部门和荟萃分析研究。

背景：本研究旨在调查之间的关联通过进行荟萃分析和病例对照横断面研究，了解人类巨细胞病毒（HCMV）感染和胃肠道癌（GIC）的风险。摘要：一项对160名GIC患者和100名对照受试者的横断面研究分析表明，基于HCMV IgM测试，GIC患者中HCMV患病率显着较高。但是，基于IgG测试的类似分析显示无显着相关性。对包括1,044位患者和991位健康受试者在内的11项研究的进一步荟萃分析显示，HCMV感染不仅是基于HCMV DNA测试的结直肠癌发生和发展的重要风险因素，而且也是基于HCMV IgM测试的GIC的重要危险因素。但是，IgG测试再次显示HCMV感染与GIC发生之间无显着关系。关键信息：总体而言，我们的研究表明HCMV感染与GIC风险增加有关。但是，有必要进行更多的研究来阐明这种关联的分子机制。
病毒学