Retinitis pigmentosa (RP) includes a group of genetic disorders that involve the loss of visual function due to mutations mainly in photoreceptors but also in other retinal cells. Apoptosis, retinal disorganization, and inflammation are common in the progression of the disease. Epigallocatechin gallate (EGCG) has been proved as beneficial in different eye diseases. Pigmented heterozygous P23H rat was used as an animal model of RP. Visual function was assessed by optomotor and electroretinogram (ERG) and circadian rhythms were evaluated by telemetry. Hepatic oxidative damage and antioxidant defenses were assessed using biochemical tests. The visual function of the EGCG P23H group was preserved, with a deterioration in the activity period and lower values in the interdaily stability parameter. Control rats treated with EGCG were less active than the sham group. EGCG increased antioxidant levels in P23H rats but reduced total hepatic antioxidant capacity by almost 42% in control rats compared to the sham group. We conclude that treatment with EGCG improves visual function and antioxidant status in P23H rats but diminishes antioxidant defenses in wild-type control animals, and slightly worsens activity circadian rhythms. Further studies are necessary to clarify the beneficial effects in disease conditions and in healthy organisms.

中文翻译：

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表没食子儿茶素没食子酸酯减缓视网膜变性，减少氧化损伤，并改变P23H大鼠的昼夜节律。

色素性视网膜炎（RP）包括一组遗传性疾病，这些遗传性疾病主要是由于感光细胞中以及其他视网膜细胞中的突变引起的视觉功能丧失。细胞凋亡，视网膜混乱和炎症在疾病的发展中很常见。表没食子儿茶素没食子酸酯（EGCG）已被证明对不同的眼疾有益。色素杂合的P23H大鼠用作RP的动物模型。通过光动力和视网膜电图（ERG）评估视觉功能，通过遥测评估昼夜节律。使用生化测试评估肝的氧化损伤和抗氧化防御。EGCG P23H组的视觉功能得以保留，但活动时间有所延长，日间稳定性参数值较低。用EGCG治疗的对照组大鼠的运动能力低于假手术组。与假手术组相比，EGCG增加了P23H大鼠的抗氧化水平，但使对照组大鼠的总肝抗氧化能力降低了近42％。我们得出的结论是，EGCG处理可改善P23H大鼠的视觉功能和抗氧化状态，但会降低野生型对照动物的抗氧化防御能力，并稍微加剧昼夜节律的活动。有必要进行进一步的研究以阐明对疾病状况和健康生物的有益作用。我们得出的结论是，EGCG处理可改善P23H大鼠的视觉功能和抗氧化状态，但会减少野生型对照动物的抗氧化防御能力，并稍微加剧昼夜节律的活动。有必要进行进一步的研究以阐明对疾病状况和健康生物的有益作用。我们得出的结论是，EGCG处理可改善P23H大鼠的视觉功能和抗氧化状态，但会降低野生型对照动物的抗氧化防御能力，并稍微加剧昼夜节律的活动。有必要进行进一步的研究以阐明对疾病状况和健康生物的有益作用。