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A Novel Paramagnetic Nanoparticle T2 Magnetic Resonance Imaging Contrast Agent With High Colloidal Stability: Polyacrylic Acid‐Coated Ultrafine Dysprosium Oxide Nanoparticles
Bulletin of the Korean Chemical Society ( IF 2.3 ) Pub Date : 2020-08-07 , DOI: 10.1002/bkcs.12074 Shanti Marasini 1 , Huan Yue 1 , Son Long Ho 1 , Hyunsil Cha 2 , Ji Ae Park 3 , Ki‐Hye Jung 3 , Adibehalsadat Ghazanfari 1 , Mohammad Yaseen Ahmad 1 , Shuwen Liu 1 , Kwon‐Seok Chae 4 , Yongmin Chang 2 , Gang Ho Lee 1
Bulletin of the Korean Chemical Society ( IF 2.3 ) Pub Date : 2020-08-07 , DOI: 10.1002/bkcs.12074 Shanti Marasini 1 , Huan Yue 1 , Son Long Ho 1 , Hyunsil Cha 2 , Ji Ae Park 3 , Ki‐Hye Jung 3 , Adibehalsadat Ghazanfari 1 , Mohammad Yaseen Ahmad 1 , Shuwen Liu 1 , Kwon‐Seok Chae 4 , Yongmin Chang 2 , Gang Ho Lee 1
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Until now, there have been limited studies on T2 magnetic resonance imaging (MRI) contrast agents (CAs) using paramagnetic nanoparticles (NPs). In this study, ultrafine dysprosium oxide (Dy2O3) NPs were synthesized as a T2 MRI CA. To obtain high biocompatibility and colloidal stability in aqueous medium for in vivo applications, they were grafted with polyacrylic acid. They displayed paramagnetism with an appreciable magnetization value at 300 K and consequently, an appreciable transverse water proton spin relaxivity (r2) value which increased as the applied MR field increased. Their potential as a T2 MRI CA was proved by taking in vivo T2 MR images in mice.
中文翻译：
具有高胶体稳定性的新型顺磁性纳米粒子T2磁共振成像造影剂：聚丙烯酸涂层超细氧化s纳米粒子。
迄今为止，关于使用顺磁性纳米粒子（NP）的T 2磁共振成像（MRI）造影剂（CA）的研究还很有限。在这项研究中，合成超细氧化（（Dy 2 O 3）NPs作为T 2 MRICA。为了在体内应用的水性介质中获得高生物相容性和胶体稳定性，将它们与聚丙烯酸接枝。他们显示出具有300 K的可磁化值的顺磁性，因此，随着所施加的MR场的增加，横向水质子自旋弛豫（r 2）值也随之增加。通过体内摄取证明了其作为T 2 MRI CA的潜力小鼠的T 2 MR图像。
更新日期：2020-08-07
中文翻译：
具有高胶体稳定性的新型顺磁性纳米粒子T2磁共振成像造影剂：聚丙烯酸涂层超细氧化s纳米粒子。
迄今为止，关于使用顺磁性纳米粒子（NP）的T 2磁共振成像（MRI）造影剂（CA）的研究还很有限。在这项研究中，合成超细氧化（（Dy 2 O 3）NPs作为T 2 MRICA。为了在体内应用的水性介质中获得高生物相容性和胶体稳定性，将它们与聚丙烯酸接枝。他们显示出具有300 K的可磁化值的顺磁性，因此，随着所施加的MR场的增加，横向水质子自旋弛豫（r 2）值也随之增加。通过体内摄取证明了其作为T 2 MRI CA的潜力小鼠的T 2 MR图像。
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