Recurrent respiratory tract infections (rRTI) in children represent a challenge in physician’s practice and raise the suspicion of an immunological defect, when allergy and other chronic respiratory diseases are excluded [1]. When major primary antibody deficiencies are excluded [2‐4], the diagnosis of Unclassified Primary Antibody Deficiency (UnPAD) or a Specific Antibody Deficiency (SAD) due to a reduced response to purified or conjugate pneumococcal polysaccharide vaccine (PPV‐SAD and PCV‐SAD, respectively) should be considered [5].

中文翻译：

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IgM，IgA和IgG对反复呼吸道感染儿童的共轭多糖反应。

儿童的反复呼吸道感染（rRTI）在排除过敏和其他慢性呼吸道疾病[1]时是医师实践的一个挑战，并增加了人们对免疫缺陷的怀疑。当排除主要的主要抗体缺陷时[2-4]，由于对纯化或结合的肺炎球菌多糖疫苗（PPV-SAD和PCV-）的反应减少，因此诊断为未分类的主要抗体缺乏症（UnPAD）或特定抗体缺乏症（SAD）。 SAD）分别应考虑[5]。