Sphingolipids: Regulators of azole drug resistance and fungal pathogenicity.,Molecular Microbiology

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Sphingolipids: Regulators of azole drug resistance and fungal pathogenicity.
Molecular Microbiology ( IF 2.6 ) Pub Date : 2020-08-07 , DOI: 10.1111/mmi.14586
Jinxing Song ₁ , Xiao Liu ₁ , Rongpeng Li ₁

Affiliation

In recent years, the role of sphingolipids in pathogenic fungi, in terms of pathogenicity and resistance to azole drugs, has been a rapidly growing field. This review describes evidence about the roles of sphingolipids in azole resistance and fungal virulence. Sphingolipids can serve as signaling molecules that contribute to azole resistance through modulation of the expression of drug efflux pumps. They also contribute to azole resistance by participating in various microbial pathways such as the unfolded protein response (UPR), pH‐responsive Rim pathway, and pleiotropic drug resistance (PDR) pathway. In addition, sphingolipid signaling and eisosomes also coordinately regulate sphingolipid biosynthesis in response to azole‐induced membrane stress. Sphingolipids are important for fungal virulence, playing roles during growth in hosts under stressful conditions, maintenance of cell wall integrity, biofilm formation, and production of various virulence factors. Finally, we discuss the possibility of exploiting fungal sphingolipids for the development of new therapeutic strategies to treat infections caused by pathogenic fungi.

中文翻译：

鞘脂：唑类药物抗性和真菌致病性的调节剂。

近年来，鞘脂在致病真菌中的作用，在致病性和对唑类药物的抗性方面，一直是一个快速发展的领域。这篇综述描述了关于鞘脂在唑类抗性和真菌毒力中的作用的证据。鞘脂可作为信号分子，通过调节药物外排泵的表达导致唑类耐药。它们还通过参与各种微生物途径，如未折叠蛋白反应 (UPR)、pH 响应性 Rim 途径和多效耐药性 (PDR) 途径，导致唑类耐药。此外，鞘脂信号传导和 eisosomes 还协同调节鞘脂生物合成以响应唑类诱导的膜应激。鞘脂对真菌毒力很重要，在压力条件下宿主的生长过程中发挥作用，维持细胞壁完整性，生物膜形成和各种毒力因子的产生。最后，我们讨论了利用真菌鞘脂开发新的治疗策略来治疗由病原真菌引起的感染的可能性。

更新日期：2020-08-07

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