Parenchymal arterioles (PAs) regulate perfusion of the cerebral microcirculation, and impaired PA endothelium‐dependent dilation occurs in dementia models mimicking chronic cerebral hypoperfusion (CCH). Epoxyeicosatrienoic acids (EETs) are vasodilators; their actions are potentiated by soluble epoxide hydrolase (sEH) inhibition. We hypothesized that chronic sEH inhibition with trifluoromethoxyphenyl‐3 (1‐propionylpiperidin‐4‐yl) urea (TPPU) would prevent cognitive dysfunction and improve PA dilation in a hypertensive CCH model.

中文翻译：

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可溶性环氧化物水解酶抑制剂可改善慢性脑灌注不足的高血压模型中的认知功能和实质动脉扩张

实质小动脉 (PAs) 调节脑微循环的灌注，在模拟慢性脑灌注不足 (CCH) 的痴呆模型中，PA 内皮依赖性扩张受损。环氧二十碳三烯酸 (EET) 是血管扩张剂；它们的作用通过可溶性环氧化物水解酶 (sEH) 抑制作用增强。我们假设用三氟甲氧基苯基-3（1-丙酰基哌啶-4-基）尿素（TPPU）长期抑制 sEH 可以预防认知功能障碍并改善高血压 CCH 模型中的 PA 扩张。