Anorexia nervosa (AN) is a severe and complex psychiatric disorder characterized by intense fear about weight gain and finalized to food‐related control behaviors. Growing interest has been demonstrated about neurobiological processes subtend to AN physiopathology. The present review aimed to collect neurostructural and neurofunctional available data from 2010 to 2019. Results have been organized according to the neuroimaging technique employed, also including a specific section on electroencephalographic results, mostly neglected in previous reviews. Diffuse cerebral vulnerability has been demonstrated and the contribution of several structures has been identified. Insula, cingulate cortex, parietal and frontal areas are primarily involved both by structural and functional perspectives. Moreover, consistent alterations in white matter integrity and brain electrical activity have been reported. Neuroimaging findings give a substantial contribution to AN pathophysiological description, also in order to understand altered but reversible processes in the passage from acute illness phase to disorder's remission, useful also for defining therapy.

中文翻译：

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神经性厌食症的多模态神经影像学。

神经性厌食症 (AN) 是一种严重而复杂的精神疾病，其特征是对体重增加的强烈恐惧，并最终导致与食物相关的控制行为。人们对 AN 病理生理学的神经生物学过程越来越感兴趣。本综述旨在收集 2010 年至 2019 年的神经结构和神经功能可用数据。结果根据所采用的神经影像技术进行组织，还包括一个关于脑电图结果的特定部分，在之前的综述中大多被忽略。已经证明了弥漫性大脑脆弱性，并且已经确定了几种结构的贡献。脑岛、扣带皮层、顶叶和额叶区域主要受结构和功能的影响。而且，已经报道了白质完整性和脑电活动的一致改变。神经影像学发现对 AN 的病理生理学描述做出了重大贡献，也是为了了解从急性疾病阶段到疾病缓解的过程中发生变化但可逆的过程，也可用于定义治疗。