Magnesium (Mg) based implants such as plates and screws are often preferred to treat bone defects because of the positive effects of magnesium in bone growth and healing. Their low corrosion resistance, however, leads to fast degradation and consequently failure before healing was completed. Previously, we developed Mg doped titanium nitrate (TiN) thin film coatings to address these limitations and demonstrated that <10 at% Mg doping led to enhanced mineralization in vitro. In the present study, in vivo performance of (Ti,Mg)N coated Ti6Al4V based plates and screws were studied in the rabbit model. Bone fractures were formed on femurs of 16 rabbits and then fixed with either (Ti,Mg)N coated (n = 8) or standard TiN coated (n = 8) plates and screws. X‐ray imaging and μCT analyses showed enhanced bone regeneration on fracture sites fixed with (Ti,Mg)N coated plates in comparison with the Mg free ones. Bone mineral density, bone volume, and callus volume were also found to be 11.4, 23.4, and 42.8% higher, respectively, in accordance with μCT results. Furthermore, while TiN coatings promoted only primary bone regeneration, (Ti,Mg)N led to secondary bone regeneration in 6 weeks. These results indicated that Mg presence in the coatings accelerated bone regeneration in the fracture site. (Ti,Mg)N coating can be used as a practical method to increase the efficiency of existing bone fixation devices of varying geometry.

中文翻译：

---

使用 (Ti,Mg)N 薄膜涂层板和螺钉评估骨愈合：兔股骨模型。

由于镁对骨骼生长和愈合的积极作用，通常首选镁 (Mg) 基植入物（例如板和螺钉）来治疗骨缺损。然而，它们的低耐腐蚀性会导致快速降解并因此在愈合完成之前失效。此前，我们开发了 Mg 掺杂的硝酸钛 (TiN) 薄膜涂层来解决这些限制，并证明 <10 at% 的 Mg 掺杂导致体外矿化增强。在本研究中，在兔子模型中研究了 (Ti,Mg)N 涂层 Ti6Al4V 基板和螺钉的体内性能。在 16 只兔子的股骨上形成骨折，然后用 (Ti,Mg)N 涂层 ( n = 8) 或标准 TiN 涂层 ( n= 8) 板和螺钉。X 射线成像和 μCT 分析显示，与不含镁的钢板相比，采用 (Ti,Mg)N 涂层钢板固定的骨折部位的骨再生增强。根据 μCT 结果，骨矿物质密度、骨体积和骨痂体积也分别高出 11.4%、23.4% 和 42.8%。此外，虽然 TiN 涂层仅促进初级骨再生，但 (Ti,Mg)N 可在 6 周内导致次级骨再生。这些结果表明，涂​​层中镁的存在加速了骨折部位的骨再生。(Ti,Mg)N 涂层可用作提高现有各种几何形状的骨固定装置效率的实用方法。