The maternal brain: Region-specific patterns of brain aging are traceable decades after childbirth.,Human Brain Mapping

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The maternal brain: Region-specific patterns of brain aging are traceable decades after childbirth.
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-08-07 , DOI: 10.1002/hbm.25152
Ann-Marie G de Lange _{1,

2,

3} , Claudia Barth ₃ , Tobias Kaufmann ₃ , Melis Anatürk _{1,

4} , Sana Suri _{1,

4} , Klaus P Ebmeier ₁ , Lars T Westlye _{2,

3,

5}

Affiliation

Pregnancy involves maternal brain adaptations, but little is known about how parity influences women's brain aging trajectories later in life. In this study, we replicated previous findings showing less apparent brain aging in women with a history of childbirths, and identified regional brain aging patterns linked to parity in 19,787 middle‐ and older‐aged women. Using novel applications of brain‐age prediction methods, we found that a higher number of previous childbirths were linked to less apparent brain aging in striatal and limbic regions. The strongest effect was found in the accumbens—a key region in the mesolimbic reward system, which plays an important role in maternal behavior. While only prospective longitudinal studies would be conclusive, our findings indicate that subcortical brain modulations during pregnancy and postpartum may be traceable decades after childbirth.

中文翻译：

母亲的大脑：特定区域的大脑衰老模式可以在产后数十年追踪到。

怀孕涉及母亲大脑的适应，但人们对胎次如何影响女性晚年大脑衰老轨迹知之甚少。在这项研究中，我们重复了之前的研究结果，即有生育史的女性大脑老化不太明显，并在 19,787 名中老年女性中确定了与胎次相关的区域大脑老化模式。通过使用大脑年龄预测方法的新颖应用，我们发现先前分娩次数较多与纹状体和边缘区域不太明显的大脑老化有关。最强的影响出现在伏隔核——中脑边缘奖赏系统的关键区域，在母性行为中发挥着重要作用。虽然只有前瞻性纵向研究才能得出结论，但我们的研究结果表明，怀孕和产后期间皮质下的大脑调节可能在分娩后几十年可以追踪。

更新日期：2020-10-14

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