Diverse Particle Carriers Prepared by Co-Precipitation and Phase Separation: Formation and Applications.,ChemPlusChem

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Diverse Particle Carriers Prepared by Co-Precipitation and Phase Separation: Formation and Applications.
ChemPlusChem ( IF 3.0 ) Pub Date : 2020-08-07 , DOI: 10.1002/cplu.202000497
Zhu Sun ₁ , Baiheng Wu _{1,

2} , Yixin Ren ₁ , Zhongzhen Wang ₁ , Chun-Xia Zhao ₃ , Mingtan Hai ₄ , David A Weitz ₄ , Dong Chen _{1,

2}

Affiliation

Nanoparticles with diverse structures and unique properties have attracted increasing attention for their widespread applications. Co‐precipitation under rapid mixing is an effective method to obtained biocompatible nanoparticles and diverse particle carriers are achieved by controlled phase separation via interfacial tensions. In this Minireview, we summarize the underlying mechanism of co‐precipitation and show that rapid mixing is important to ensure co‐precipitation. In the binary polymer system, the particles can form four different morphologies, including occluded particle, core‐shell capsule, dimer particle, and heteroaggregate, and we demonstrate that the final morphology could be controlled by surface tensions through surfactant, polymer composition, molecular weight, and temperature. The applications of occluded particles, core‐shell capsules and dimer particles prepared by co‐precipitation or microfluidics upon the regulation of interfacial tensions are discussed in detail, and show great potential in the areas of functional materials, colloidal surfactants, drug delivery, nanomedicine, bio‐imaging, displays, and cargo encapsulation.

中文翻译：

通过共沉淀和相分离制备的多种颗粒载体：形成和应用。

具有多种结构和独特性能的纳米颗粒因其广泛的应用而引起了越来越多的关注。快速混合下的共沉淀是获得生物相容性纳米粒子的有效方法，并且通过界面张力可控的相分离可实现多种粒子载体。在此Minireview中，我们总结了共沉淀的基本机制，并表明快速混合对于确保共沉淀很重要。在二元聚合物系统中，颗粒可以形成四种不同的形态，包括被封闭的粒子，核壳胶囊，二聚体粒子和杂聚集体，并且我们证明了最终的形态可以通过表面活性剂，聚合物组成，分子量的表面张力来控制。和温度。堵塞颗粒的应用

更新日期：2020-08-07

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