Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs.,ChemBioChem

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Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-08-06 , DOI: 10.1002/cbic.202000416
Nils Janson ₁ , Tobias Krüger ₁ , Lennard Karsten ₂ , Mareile Boschanski ₃ , Thomas Dierks ₃ , Kristian M Müller ₂ , Norbert Sewald ₁

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Increased efficiency: The combination of azide‐functionalized HIPS or tandem Knoevenagel ligation reagents and SPAAC enables the fast and efficient mono‐ and double‐derivatization of proteins with stoichiometric amounts of DBCO‐modified payloads at low concentration.