Adult Neurogenesis in the Olfactory System: Improving Performance for Difficult Discrimination Tasks?,BioEssays

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Adult Neurogenesis in the Olfactory System: Improving Performance for Difficult Discrimination Tasks?
BioEssays ( IF 3.2 ) Pub Date : 2020-08-07 , DOI: 10.1002/bies.202000065
Ioanna Kouremenou ₁ , Michael Piper _{1,

2} , Oressia Zalucki ₁

Affiliation

What is the function of new neurons entering the olfactory bulb? Many insights regarding the molecular control of adult neurogenesis have been uncovered, but the purpose of new neurons entering the olfactory bulb has been difficult to ascertain. Here, studies investigating the role of adult neurogenesis in olfactory discrimination in mice are reviewed. Studies in which adult neurogenesis is affected are highlighted, with a focus on the role of environment enrichment and what happens during ageing. There is evidence for a role of adult neurogenesis in fine discrimination tasks, as underscored by studies that enhance adult neurogenesis. This is also observed in ageing studies, where older mice with reduced levels of adult neurogenesis perform poorly in olfactory discrimination. Differences in methodology that could account for alternative conclusions, and the importance of specificity in methods being used to investigate the effect of adult neurogenesis in olfactory performance are emphasized.

中文翻译：

嗅觉系统中的成人神经发生：提高困难辨别任务的表现？

进入嗅球的新神经元有什么功能？许多关于成人神经发生的分子控制的见解已被发现，但新神经元进入嗅球的目的一直难以确定。在这里，回顾了调查成年神经发生在小鼠嗅觉辨别中的作用的研究。强调了成人神经发生受到影响的研究，重点是环境丰富的作用以及衰老过程中会发生什么。有证据表明成人神经发生在精细辨别任务中的作用，正如增强成人神经发生的研究所强调的那样。这也在衰老研究中观察到，成年神经发生水平降低的老年小鼠在嗅觉辨别方面表现不佳。

更新日期：2020-09-24

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