Background

Arterial stiffness is an independent determinant of cardiovascular and cerebrovascular risks. The relationship between the increase in arterial stiffness parameters and the severity of stroke has been shown in previous studies. We aimed to investigate the association between clinical improvement and changes in arterial stiffness parameters in patients presenting acute ischemic stroke.

Methods

A total of 107 patients were enrolled in this study. On the first and seventh day of the hospitalization, 24 h non-invasive blood pressure was monitored and arterial stiffness parameters were measured. The National Institutes of Health Stroke Scale (NIHSS) was used to determine the severity of stroke, and the Modified Rankin Scale was used to determine dependency and to evaluate functional improvements.

Results

Arterial stiffness parameters of augmentation index (AIx@75) and pulse wave velocity (PWV) were significantly higher in patients who died during hospitalization than patients who were discharged (respectively p <0.001, p = 0.04). In the group with clinical improvement, PWV values measured on the seventh day were significantly lower than PWV values measured on the first day (p = 0.032). When the changes in PWV value measured on the first and seventh day for both groups were analyzed using mixed ANOVA test, p value were significant (p = 0.033). Multivariate binary logistic regression analyses showed that negatively change in PWV and CDBP independently predicts the clinical improvement.

Conclusions

Increased AIx@75 and PWV appear to be associated with higher in-hospital mortality rates in patients with acute ischemic stroke. Additionally, clinical improvement in patients with ischemic stroke is associated with a decrease in PWV .

中文翻译：

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脉搏波速度的降低与缺血性卒中患者的临床改善相关

背景

动脉僵硬度是心血管和脑血管风险的独立决定因素。在先前的研究中已经显示出动脉僵硬度参数的增加与中风严重程度之间的关系。我们旨在研究急性缺血性卒中患者的临床改善与动脉僵硬度参数变化之间的关联。

方法

本研究共纳入107位患者。在住院的第一天和第七天，监测24小时无创血压并测量动脉僵硬度参数。美国国立卫生研究院卒中量表（NIHSS）用于确定卒中的严重程度，改良兰金量表用于确定依赖性并评估功能改善。

结果

住院期间死亡的患者的动脉增高指数（AIx @ 75）和脉搏波速度（PWV）的参数显着高于出院患者（分别为p <0.001，p  = 0.04）。在具有临床改善的组中，第七天测得的PWV值明显低于第一天测得的PWV值（p  = 0.032）。当使用混合ANOVA测试分析两组在第一天和第七天测得的PWV值变化时，p值显着（p  = 0.033）。多元二元逻辑回归分析表明，PWV和CDBP的负变化独立预测了临床改善。

结论

在急性缺血性中风患者中，AIx @ 75和PWV升高似乎与更高的院内死亡率相关。另外，缺血性中风患者的临床改善与PWV的降低有关。