Association between TNFA, IL10 and IL18 promoter gene variants and cognitive functions in patients with relapsing-remitting multiple sclerosis,Journal of Neuroimmunology

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Association between TNFA, IL10 and IL18 promoter gene variants and cognitive functions in patients with relapsing-remitting multiple sclerosis
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.jneuroim.2020.577357
Anastasiya Georgieva Trenova ₁ , Lyuba Dineva Miteva ₂ , Spaska Angelova Stanilova ₂

Affiliation

OBJECTIVES To investigate the relationship between TNFA-308G > A, IL10-1082A > G, IL18-607C > A, and cognitive functioning in relapsing-remitting multiple sclerosis (RRMS). RESULTS In the patients' group: AG genotype of TNFA-308G > A was associated with higher serum tumor necrosis factor-alpha (TNF-alpha) than GG genotype, and higher TNF-alpha levels correlated with poorer results on Symbol Digit Modalities Test; CC genotype of IL18-607C > A was related to lower score on Isaacs test, compared to AC variant; AA genotype of IL10-1082A > G was associated with abnormally low results on Paced Auditory Series Addition Test. CONCLUSIONS TNFA-308G > A, IL10-1082A > G and IL18-607C > A gene variants may be associated with impaired cognitive functions in RRMS patients.

中文翻译：

复发缓解型多发性硬化患者 TNFA、IL10 和 IL18 启动子基因变异与认知功能的关系

目的研究 TNFA-308G > A、IL10-1082A > G、IL18-607C > A 与复发缓解型多发性硬化症 (RRMS) 认知功能之间的关系。结果在患者组中：与GG基因型相比，AG基因型TNFA-308G > A与更高的血清肿瘤坏死因子-α（TNF-α）相关，较高的TNF-α水平与符号数字模态测试的较差结果相关；与 AC 变体相比，IL18-607C > A 的 CC 基因型与 Isaacs 测试的较低分数有关；IL10-1082A > G 的 AA 基因型与起搏听觉系列加法测试的异常低结果相关。结论 TNFA-308G > A、IL10-1082A > G 和 IL18-607C > A 基因变异可能与 RRMS 患者的认知功能受损有关。

更新日期：2020-10-01

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