A new composite, AgPW@PDA@Nisin, with shell-core structure was successfully synthesized by a polydopamine (PDA) surfaced conjugated nisin (an antibacterial 34 amino acid polycyclic peptide) as shell and polyoxometalates (Ag₃PW₁₂O₄₀ = AgPW) as core. The composite was characterized by the zeta potential, scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction analysis (XRD), fourier transform infrared (FT-IR). The AgPW@PDA@Nisin showed flower hierarchical structure and potential antibacterial activity against S. aureus ATCC29213. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of it were 4 and 32 μg/mL. AgPW@PDA@Nisin nanoflowers-induced bacterial death bears the characteristic of cell morphology, membrane integrity and permeability changing, nucleotide leakage. It indicated that the AgPW@PDA@Nisin interfere with the cell membrane, resulting in antibacterial activity against S. aureus. The cytotoxicity of the nanoflowers was low on HDF-a (human dermal fibroblasts) cells. A new class of hybrid inorganic-organic nanoflowers based on polyoxometalates and nisin with enhanced antibacterial properties can be developed for food preservation.

以聚多巴胺（PDA）为表面的共轭乳酸链球菌肽（一种抗菌的34氨基酸多环肽）作为壳和多金属氧酸盐（Ag ₃ PW ₁₂ O ₄₀  = AgPW）成功合成了具有壳核结构的新型复合材料AgPW@PDA@Nisin作为核心。通过zeta电位、扫描电子显微镜(SEM)、透射电子显微镜(TEM)、X射线衍射分析(XRD)、傅里叶变换红外(FT-IR)对复合材料进行表征。AgPW@PDA@Nisin 显示出花的层次结构和对金黄色葡萄球菌的潜在抗菌活性ATCC29213。其最低抑菌浓度（MIC）和最低杀菌浓度（MBC）分别为4和32 μg/mL。AgPW@PDA@Nisin 纳米花诱导的细菌死亡具有细胞形态、膜完整性和通透性改变、核苷酸泄漏等特征。这表明 AgPW@PDA@Nisin 干扰细胞膜，导致对金黄色葡萄球菌的抗菌活性。纳米花对 HDF-a（人真皮成纤维细胞）细胞的细胞毒性很低。可以开发一种基于多金属氧酸盐和乳酸链球菌肽的新型杂化无机-有机纳米花，具有增强的抗菌性能，可用于食品保鲜。