Cognitive behaviors, such as episodic memory formation, are complex processes involving coordinated activity in multiple brain regions. However, much of the research on hormonal regulation of cognition focuses on manipulation of one region at a time or provides a single snapshot of how a systemic treatment affects multiple brain regions without investigating how these regions might interact to mediate hormone effects. Here, we use estrogenic regulation of episodic memory as an example of how circuit-based approaches may be incorporated into future studies of hormones and cognition. We first review basic episodic memory circuitry, rapid mechanisms by which 17β-estradiol can alter circuit activity, and current knowledge about 17β-estradiol's effects on episodic memory. Next, we outline approaches that researchers can employ to consider circuit effects in their estrogen research and provide examples of how these methods have been used to examine hormonal regulation of memory and other behaviors.

中文翻译：

---

它需要一个神经村：基于电路的情景记忆雌激素调节方法

认知行为，例如情景记忆的形成，是涉及多个大脑区域协调活动的复杂过程。然而，关于认知的激素调节的大部分研究都集中在一次操纵一个区域，或者提供系统治疗如何影响多个大脑区域的单一快照，而没有研究这些区域如何相互作用以调节激素效应。在这里，我们以情景记忆的雌激素调节为例，说明如何将基于电路的方法纳入未来的激素和认知研究中。我们首先回顾了基本的情景记忆电路、17β-雌二醇改变电路活动的快速机制，以及目前关于 17β-雌二醇对情景记忆的影响的知识。下一个，