Oscillations of the cellular circadian clock have emerged as an important regulator of many physiological processes, both in health and in disease. One such process, cellular proliferation, is being increasingly recognized to be affected by the circadian clock. Here, we review how a combination of experimental and theoretical work has furthered our understanding of the way circadian clocks couple to the cell cycle and play a role in tissue homeostasis and cancer. Finally, we discuss recently introduced methods for modeling coupling of clocks based on techniques from survival analysis and machine learning and highlight their potential importance for future studies.

中文翻译：

---

昼夜节律对细胞增殖的影响：理论和实验的见解。

细胞昼夜节律时钟的振荡已成为健康和疾病中许多生理过程的重要调节器。人们日益认识到一种这样的过程，即细胞增殖，受到昼夜节律时钟的影响。在这里，我们回顾了实验和理论工作的结合如何加深了我们对生物钟与细胞周期耦合并在组织稳态和癌症中发挥作用的理解。最后，我们讨论基于生存分析和机器学习技术的时钟耦合模型的最新介绍方法，并强调它们对未来研究的潜在重要性。