BACKGROUND AND PURPOSE Satellite sign is a novel neuroimaging marker for predicting hematoma expansion (HE), which is closely related to unfavorable prognosis in patients with spontaneous intracerebral hemorrhage (ICH). However, the predictive value of satellite sign varied according to previous studies. Thus, we conduct this meta-analysis to systematically review the application value of satellite sign in related studies. METHODS We searched the literature in PubMed, Embase, and Web of Science from inception to April 10, 2020. Effect values, including sensitivity, specificity, and positive and negative likelihood ratio were pooled to assess the diagnostic value of satellite sign for HE in patients with ICH. RESULTS The meta-analysis included five studies with a total of 1493 patients. Results showed that the pooled diagnostic sensitivity and specificity were 0.50 (95 % CI, 0.31-0.70) and 0.71 (95 % CI, 0.56-0.83), respectively. In addition, the pooled positive and negative likelihood ratios were 1.7 (95 % CI, 1.5-2.1) and 0.70 (95 % CI, 0.54-0.89), respectively. No significant publication bias was found. CONCLUSION Satellite sign exhibited moderate sensitivity and specificity for predicting HE in patients with ICH. Further studies are needed to explore its value in clinical application.

中文翻译：

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卫星征对脑出血血肿扩大的预测准确性：Meta分析

背景与目的卫星征是一种预测血肿扩大（HE）的新型神经影像学标志物，其与自发性脑出血（ICH）患者的不良预后密切相关。然而，根据先前的研究，卫星标志的预测价值各不相同。因此，我们进行这项荟萃分析，以系统地回顾卫星标志在相关研究中的应用价值。方法 我们在 PubMed、Embase 和 Web of Science 中检索了从开始到 2020 年 4 月 10 日的文献。汇集效应值，包括敏感性、特异性以及阳性和阴性似然比，以评估卫星征对患者 HE 的诊断价值与 ICH。结果 荟萃分析包括五项研究，共 1493 名患者。结果显示，汇总的诊断敏感性和特异性分别为 0.50（95% CI，0.31-0.70）和 0.71（95% CI，0.56-0.83）。此外，汇总的阳性和阴性似然比分别为 1.7（95% CI，1.5-2.1）和 0.70（95% CI，0.54-0.89）。未发现显着的发表偏倚。结论卫星征在预测 ICH 患者的 HE 方面表现出中等敏感性和特异性。需要进一步的研究来探索其临床应用价值。结论卫星征在预测 ICH 患者的 HE 方面表现出中等敏感性和特异性。需要进一步的研究来探索其临床应用价值。结论卫星征在预测 ICH 患者的 HE 方面表现出中等敏感性和特异性。需要进一步的研究来探索其临床应用价值。