Malaria, a nocuous disease, which has become a major challenge for the health resulting in deaths of millions of people around the globe. Malaria is a parasitic disease propagated by mosquitoes and infects the human beings. Several species of Plasmodium are responsible for this life-threatening disease and Plasmodium falciparum being the most virulent. In order to eradicate the malarial parasite, the researchers are making consistent efforts in synthesizing new antimalarial drug candidates by paying attention to the various drug targets. In this manuscript, the main focus is on the antimalarial activity of numerous heterocyclic compounds reported by the researchers since 2010 against the different strains of Plasmodium. Antimalarial activities of the two and three nitrogen-containing heterocycles along with their structure–activity relationship are described.

中文翻译：

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含两个或三个氮原子的杂环化合物的抗疟活性

疟疾是一种恶性疾病，已成为健康的主要挑战，导致全球数百万人死亡。疟疾是由蚊子传播并感染人类的​​寄生虫病。疟原虫的几种物种是造成这种威胁生命的疾病的原因，恶性疟原虫是最致命的疾病。为了消除疟原虫，研究人员通过关注各种药物靶点，在合成新的抗疟药物候选药物方面做出了不懈的努力。在此手稿中，主要重点是研究人员自2010年以来报告的许多杂环化合物对不同疟原虫菌株的抗疟活性。描述了两个和三个含氮杂环的抗疟活性及其结构-活性关系。