Multiple sclerosis (MS) is a multifactorial, central nervous system, immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration. Evidence suggests a steady rise in MS prevalence over the past five decades in the United States and around the world. Even with increased understanding of immunology, the specific etiological trigger of MS remains unknown. Evidence suggests that oxidative/nitroxidative stress is an important contributor to MS etiology, progression, and clinical symptoms. A multifaceted treatment approach aimed at counteracting oxidative/nitroxidative stress including MS disease–modifying medications, Mediterranean style diet, stress-relieving activities, smoking and alcohol cessation, exercise, and peer support programs is the best way to treat the disease.

多发性硬化症 (MS) 是一种多因素、中枢神经系统、免疫介导的疾病，其特征是炎症、脱髓鞘和神经变性。有证据表明，在过去的五年中，美国和世界各地的 MS 患病率稳步上升。即使对免疫学有了更多的了解，MS 的具体病因触发因素仍然未知。有证据表明，氧化/氮氧化应激是 MS 病因、进展和临床症状的重要因素。旨在抵消氧化/氮氧化应激的多方面治疗方法，包括改善 MS 疾病的药物、地中海式饮食、缓解压力的活动、戒烟和戒酒、锻炼和同伴支持计划，是治疗该疾病的最佳方法。