Background Migraine in children and adolescents is very common and can be associated with equivalents, psychiatric disorders, or abnormal electroencephalogram findings. Neurogenic inflammation is involved in migraine pathogenesis where pro-inflammatory cytokines play a significant role. Recent studies have demonstrated that serum bilirubin can be considered as an antioxidant and cytoprotective agent and that its concentration may be influenced in migraine by neurogenic inflammation. Various studies have observed reduced serum bilirubin in migrainous adults, and few studies investigated the association between serum bilirubin and migraine in children and adolescents. Objectives To study the association between serum bilirubin and migraine in children and adolescents. Patients and method Serum samples were collected from 40 migrainous children and adolescents and from 40 controls. Total, direct, and indirect bilirubin concentrations were measured. Headache features, migraine equivalents, psychiatric comorbidity, and electroencephalogram findings were documented in migraineurs. Results Serum total, direct, and indirect bilirubin concentrations were significantly lower in migraineurs than controls. This was statistically significant associated with abnormal electroencephalogram findings during headache-free periods and not statistically significant associated with any headache feature, abnormal electroencephalogram findings during headache attacks, or psychiatric comorbidity. Conclusion Serum bilirubin concentration is lower in migrainous children and adolescents compared to control, with no association with specific migraine type or features, and thus may be considered a useful marker for neurogenic inflammation in migraine.

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儿童和青少年血清胆红素与偏头痛的关系

背景 儿童和青少年偏头痛非常常见，可能与偏头痛、精神障碍或脑电图异常相关。神经源性炎症参与偏头痛发病机制，其中促炎细胞因子发挥重要作用。最近的研究表明，血清胆红素可以被认为是一种抗氧化剂和细胞保护剂，它的浓度可能会在偏头痛中受到神经源性炎症的影响。各种研究都观察到偏头痛成人的血清胆红素降低，很少有研究调查儿童和青少年血清胆红素与偏头痛之间的关系。目的研究儿童和青少年血清胆红素与偏头痛的关系。患者和方法 从 40 名偏头痛儿童和青少年以及 40 名对照组收集血清样本。测量了总、直接和间接胆红素浓度。在偏头痛患者中记录了头痛特征、偏头痛等同物、精神共病和脑电图结果。结果偏头痛患者的血清总胆红素、直接和间接胆红素浓度显着低于对照组。这与无头痛期间的异常脑电图结果有统计学意义相关，而与任何头痛特征、头痛发作期间的异常脑电图结果或精神共病无统计学意义。结论 偏头痛儿童青少年血清胆红素浓度低于对照组，