The purpose of this meta-analysis was to evaluate the diagnostic value of D-dimer in detecting periprosthetic joint infection (PJI). A systematic search and screening of relevant studies was performed in the databases PubMed, Web of Science, and Embase using the following medical subject headings (MeSH) or keywords: “arthroplasty or joint prosthesis or joint replacement or periprosthetic joint or prosthetic joint”, “infection or infectious or infected”, and “D-dimer or serum D-dimer or plasma D-dimer or fibrin degradation products”. Data were subsequently analysed and processed using Meta-Disc. Seven studies with 1285 patients were included in this meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.75 (95% confidence interval [CI] 0.70–0.79), 0.69 (95% CI 0.66–0.72), 3.01 (95% CI 1.84–4.93), 0.32 (95% CI 0.19–0.53), and 10.20 (95% CI 3.63–28.64), respectively. Subgroup analyses showed that the use of serum D-dimer had better sensitivity and specificity than plasma D-dimer for the diagnosis of PJI. Serum D-dimer was shown to have a better diagnostic value than plasma D-dimer for the diagnosis of PJI. Further research is required for clarification.

中文翻译：

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血清和/或血浆D-二聚体的荟萃分析在假体周围关节感染的诊断中。

这项荟萃分析的目的是评估D-二聚体在检测假体周围关节感染（PJI）中的诊断价值。在PubMed，Web of Science和Embase数据库中使用以下医学主题词（MeSH）或关键字对相关研究进行了系统的搜索和筛选：“人工关节置换术或关节假体或关节置换术或假体周围关节或假体关节”，“感染或传染性或感染性”，以及“ D-二聚体或血清D-二聚体或血浆D-二聚体或纤维蛋白降解产物”。随后使用Meta-Disc分析和处理数据。这项荟萃分析纳入了针对1285名患者的七项研究。合并的敏感性，特异性，阳性似然比，阴性似然比和诊断比值比分别为0.75（95％置信区间[CI] 0.70-0.79），0.69（95％CI 0）。66-0.72），3.01（95％CI 1.84-4.93），0.32（95％CI 0.19-0.53）和10.20（95％CI 3.63-28.64）。亚组分析显示，使用血清D-二聚体比血浆D-二聚体对PJI的诊断具有更好的敏感性和特异性。血清D-二聚体对PJI的诊断具有比血浆D-二聚体更好的诊断价值。需要进一步研究以澄清。