Microfluidic lumen-based systems for advancing tubular organ modeling.,Chemical Society Reviews

当前位置： X-MOL 学术 › Chem. Soc. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Microfluidic lumen-based systems for advancing tubular organ modeling.
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-08-06 , DOI: 10.1039/d0cs00705f
María Virumbrales-Muñoz ₁ , José M Ayuso ₂ , Max M Gong ₃ , Mouhita Humayun ₁ , Megan K Livingston ₁ , Karina M Lugo-Cintrón ₁ , Patrick McMinn ₁ , Yasmín R Álvarez-García ₁ , David J Beebe ₄

Affiliation

Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and physiology of tubular organs. These technologies can mimic human pathophysiology and predict drug response, having profound implications for drug discovery and development. Herein, we review progress in the development of microfluidic lumen-based models from the 2000s to the present. The core of the review discusses models for mimicking blood vessels, the respiratory tract, the gastrointestinal tract, renal tubules, and liver sinusoids, and their application to modeling organ-specific diseases. We also highlight emerging application areas, such as the lymphatic system, and close the review discussing potential future directions.

中文翻译：

基于微流体腔的系统，用于推进管状器官建模。

基于微流体腔的系统是概括管状器官的解剖学和生理学的微型模型。这些技术可以模仿人类病理生理学并预测药物反应，对药物发现和开发具有深远的影响。在此，我们回顾了 2000 年代至今基于微流体腔的模型的开发进展。该综述的核心讨论了模拟血管、呼吸道、胃肠道、肾小管和肝窦的模型及其在器官特异性疾病建模中的应用。我们还强调了新兴的应用领域，例如淋巴系统，并结束了讨论潜在未来方向的审查。

更新日期：2020-09-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11