In this work, a simple and sensitive method based on Fe₃O₄/multi-walled carbon nanotubes/ionic liquid (Fe₃O₄/MWCNTs/IL) as the adsorbent for magnetic solid phase extraction coupled with high performance liquid chromatography was developed for the determination of trace fluoroquinolones in foods. After a simple one-pot solvothermal synthesis, Fe₃O₄/MWCNTs were further modified with an amine-terminated ionic liquid to enhance their dispersibility and extraction capacity. The morphology, structure and magnetic properties of the composite adsorbent were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction spectrometry and vibrating-sample magnetometry. Under the optimized extraction and detection conditions, the studied fluoroquinolones were enriched effectively and separated well and their UV signals were linear to their concentrations in the range of 4–1000 ng mL⁻¹, with correlation coefficients ranging from 0.9958 to 0.9990. The enrichment factors were 29.1–43.9 fold and the limits of detection were 0.33–0.78 ng mL⁻¹. The spiked recoveries were 85.4–105.9% for milk and 85.2–103.7% for pork samples, with relative standard deviations of 0.8–5.7%. The developed method provided a fast, sensitive and reliable determination platform for fluoroquinolones in complex real samples.

中文翻译：

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离子液体改性的Fe3O4 / MWCNTs作为吸附剂用于磁性固相萃取和HPLC的测定食品中的氟喹诺酮类药物。

在这项工作中，开发了一种以Fe ₃ O ₄ /多壁碳纳米管/离子液体（Fe ₃ O ₄ / MWCNTs / IL）为磁性固相萃取吸附剂并结合高效液相色谱的简单而灵敏的方法。用于食品中痕量氟喹诺酮类的测定。经过简单的一锅溶剂热合成，Fe ₃ O ₄/ MWCNTs用胺封端的离子液体进一步修饰，以增强其分散性和萃取能力。通过透射电子显微镜，X射线光电子能谱，傅立叶变换红外光谱，X射线衍射能谱和振动样品磁能谱对复合吸附剂的形貌，结构和磁性进行了表征。在优化的提取和检测条件下，所研究的氟喹诺酮类有效富集并分离良好，其紫外线信号与其浓度在4–1000 ng mL ^-1范围内呈线性关系，相关系数范围为0.9958至0.9990。富集因子为29.1–43.9倍，检出限为0.33–0.78 ng mL ^-1。牛奶和猪肉样品的加标回收率分别为85.4–105.9％和85.2–103.7％，相对标准偏差为0.8–5.7％。所开发的方法为复杂的实际样品中的氟喹诺酮类提供了快速，灵敏和可靠的测定平台。