Quercetin is a natural flavonoid with potential anticancer properties without significant cytotoxicity in normal tissues. However, the effects of quercetin on Ehrlich ascites carcinoma (EAC) have not yet been clarified. The study aimed to show the antitumoral effect of quercetin through argyrophilic nucleolar organizer region (AgNOR) protein synthesis in mice carrying EAC. Thirty mice were used in the experiment (negative control (n = 6), tumor control (n = 8), quercetin 50 mg/kg (n = 8), and quercetin 100 mg/kg (n = 8) intravenously). The animals were euthanized on the 14th day, and the solid tumors were removed. Then, the total AgNOR area/nuclear area (TAA/NA) and average AgNOR number were calculated for each mice and the immunoreactivity of the factor VIII protein in tumor was evaluated. Tumor volumes and animal weights were statistically significant compared to the tumor control group (p < 0.05). Statistically significant differences were observed between the groups in terms of TAA/NA ratio (p < 0.05). Factor VIII expressions decreased in quercetin groups compared to control tumor tissue (p < 0.05). The current study showed that quercetin has an important function against cancer development.

槲皮素是一种天然黄酮类化合物，具有潜在的抗癌特性，对正常组织没有显着的细胞毒性。然而，槲皮素对艾氏腹水癌（EAC）的影响尚未阐明。该研究旨在通过在携带 EAC 的小鼠中通过嗜银核仁组织区 (AgNOR) 蛋白合成显示槲皮素的抗肿瘤作用。实验中使用30只小鼠（阴性对照（n =6）、肿瘤对照（n =8）、槲皮素50mg/kg（n =8）和槲皮素100mg/kg（n= 8) 静脉注射)。第14天对动物实施安乐死，取出实体瘤。然后，计算每只小鼠的总 AgNOR 面积/核面积 (TAA/NA) 和平均 AgNOR 数，并评估因子 VIII 蛋白在肿瘤中的免疫反应性。与肿瘤对照组相比，肿瘤体积和动物重量具有统计学意义（p < 0.05）。就 TAA/NA 比率而言，组间观察到统计学上的显着差异 ( p < 0.05)。与对照肿瘤组织相比，槲皮素组中因子 VIII 的表达降低（p < 0.05）。目前的研究表明，槲皮素对癌症的发展具有重要作用。