Objective

The goal of this study was to explore the metabolic syndrome–associated phenotype of osteoarthritis by investigating the cross-sectional associations of glycemic markers and serum lipids with knee cartilage composition and structural abnormalities in middle-aged adults.

Design

Twenty participants between 40 to 70 years of age with Kellgren-Lawrence score 0-1 in at least one knee were recruited at a single center. Knee cartilage composition was assessed using 3.0 T cartilage T₂ and T_1ρ mapping. Evaluation of structural knee abnormalities was performed using the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). Linear regression was used to assess the associations of standardized fasting glucose (FG), hemoglobin A1c (HbA1c), insulin, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), non-HDL cholesterol, and triglycerides with cartilage T₂ and T_1ρ as well as WORMS subscores, adjusting for body mass index.

Results

Higher FG and higher HbA1c were associated with higher WORMS meniscus sum (beta coefficient 1.31 [95% confidence interval (CI): 0.57, 2.05], P = 0.002 per standard deviation [SD] increase in FG; beta coefficient 0.90 [95% CI: 0.07, 1.73], P = 0.035 per SD increase in HbA1c). Also, higher total cholesterol and higher non-HDL cholesterol were associated with higher WORMS cartilage sum (beta coefficient 0.94 [95% CI: 0.01, 1.86], P = 0.048 per SD increase in total cholesterol; beta coefficient 1.05 [95% CI: 0.14, 1.96], P = 0.03 per SD increase in non-HDL cholesterol).

Conclusions

Higher FG and HbA1c were associated with increased meniscal degeneration while higher total and non-HDL cholesterol were associated with increased cartilage degeneration.

中文翻译：

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使用 MRI 研究代谢生物标志物与膝关节软骨成分和结构异常的关联：一项初步研究。

客观的

本研究的目的是通过调查血糖标志物和血脂与中年成人膝关节软骨成分和结构异常的横断面关联来探索与代谢综合征相关的骨关节炎表型。

设计

在一个中心招募了 20 名 40 至 70 岁且 Kellgren-Lawrence 至少一个膝关节评分为 0-1 的参与者。使用 3.0 T 软骨 T ₂和 T _1ρ映射评估膝关节软骨成分。使用改良的全器官磁共振成像评分 (WORMS) 对结构性膝关节异常进行评估。线性回归用于评估标准化空腹血糖 (FG)、血红蛋白 A1c (HbA1c)、胰岛素、总胆固醇、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)、非 HDL 胆固醇和甘油三酯的相关性软骨 T ₂和 T _1ρ以及 WORMS 子评分，根据体重指数进行调整。

结果

较高的 FG 和较高的 HbA1c 与较高的 WORMS 半月板总和相关（β 系数 1.31 [95% 置信区间 (CI): 0.57, 2.05]，每增加一个标准差 [SD] P = 0.002 [SD]；β 系数 0.90 [95% CI] : 0.07, 1.73]，HbA1c 每增加一个 SD ， P = 0.035）。此外，较高的总胆固醇和较高的非 HDL 胆固醇与较高的 WORMS 软骨总和相关（β 系数 0.94 [95% CI：0.01, 1.86]，P = 0.048/SD 总胆固醇增加；β 系数 1.05 [95% CI： 0.14, 1.96]，P = 0.03/SD 非 HDL 胆固醇增加）。

结论

较高的 FG 和 HbA1c 与增加的半月板退化相关，而较高的总胆固醇和非 HDL 胆固醇与增加的软骨退化相关。