Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion.,Organic Letters

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Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion.
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-06 , DOI: 10.1021/acs.orglett.0c02307
Yang Yuan ₁ , Ye Wang ₁ , Yuanyang Mu ₁ , Murong Xu ₁ , Siyi Fu ₁ , Lingkai Kong ₂ , Yanzhong Li ₁

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A novel and efficient synthesis of aza-eight-membered ring-fused indolines has been developed. This process is realized by zinc-catalyzed C2 alkylation of indoles and subsequent base-promoted ring expansion of the newly formed six-membered ring with alkynes. Easily accessible starting materials, good functional group tolerance, and high atom economy make this procedure attractive.

中文翻译：

锌催化的吲哚的C2烷基化引发的氮杂八元环稠合二氢吲哚的合成及随后的碱促进的环扩展。

已经开发了新颖且有效的氮杂八元环稠合二氢吲哚合成方法。该过程是通过锌催化的吲哚的C2烷基化以及随后新形成的带有炔烃的六元环的碱促进的环扩展来实现的。容易获得的起始原料，良好的官能团耐受性和高原子经济性使该方法具有吸引力。

更新日期：2020-08-21

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