Pd/Cu-Catalyzed Domino Cyclization/Deborylation of Alkene-Tethered Carbamoyl Chloride and 1,1-Diborylmethane.,Organic Letters

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Pd/Cu-Catalyzed Domino Cyclization/Deborylation of Alkene-Tethered Carbamoyl Chloride and 1,1-Diborylmethane.
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-05 , DOI: 10.1021/acs.orglett.0c02211
Chenhuan Zhang ₁ , Xianqing Wu ₁ , Chenchen Wang ₁ , Chengxi Zhang ₁ , Jingping Qu ₁ , Yifeng Chen ₁

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Reported herein is a palladium/copper cooperative-catalyzed dicarbofunctionalization of alkene-tethered carbamoyl chlorides with 1,1-diborylmethane. This cyclization/deborylation cascade strategy allows for the expedient formation of the versatile borylated 3,3-disubstituted oxindole skeleton, allowing for further functionalization via the derivatization of the carbon–boron bond.

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