Neutralizing antibodies elicited by HIV-1 coevolve with viral Envs in distinctive patterns, in some cases acquiring substantial breadth. Here we show that primary HIV-1 Envs, when expressed by simian-human immunodeficiency viruses in rhesus macaques, elicited patterns of Env-antibody coevolution strikingly similar to those in humans. This included conserved immunogenetic, structural and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertions and deletions leading to virus persistence. The structure of one rhesus antibody, capable of neutralizing 49% of a 208-strain panel, revealed a V2-apex mode of recognition like that of human bNAbs PGT145/PCT64-35M. Another rhesus antibody bound the CD4-binding site by CD4 mimicry mirroring human bNAbs 8ANC131/CH235/VRC01. Virus-antibody coevolution in macaques can thus recapitulate developmental features of human bNAbs, thereby guiding HIV-1 immunogen design.

中文翻译：

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在猕猴中导致中和广度的HIV-1 Env抗体进化的概述。

HIV-1引发的中和性抗体与病毒Envs以独特的方式进化，在某些情况下获得了广泛的传播。在这里，我们显示，当猿猴-人免疫缺陷病毒在猕猴中表达时，主要的HIV-1 Envs引起的Env-抗体共同进化模式与人类中的相似。这包括用于表位识别的保守免疫遗传，结构和化学解决方案，以及导致病毒持续存在的精确Env-氨基酸取代，插入和缺失。能够中和208株菌株49％的一种恒河猴抗体的结构揭示了V2顶点识别模式，类似于人bNAbs PGT145 / PCT64-35M。另一种恒河猴抗体通过CD4模仿人类bNAb 8ANC131 / CH235 / VRC01的方式结合CD4结合位点。