The spread of COVID-19 is a global concern that has taken a toll on entire human health. Researchers across the globe has been working in devising the strategies to combat this dreadful disease. Studies focused on genetic variability helps design effective drugs and vaccines. Considering this, the present study entails the information regarding the genome-wide mutations detected in the 108 SARS CoV-2 genomes worldwide. We identified a few hypervariable regions localized in orf1ab, spike, and nucleocapsid gene. These nucleotide polymorphisms demonstrated their effect on both codon usage as well as amino acid usage pattern. Altogether the present study provides valuable information that would be helpful to ongoing research on 2019-nCoV vaccine development.

中文翻译：

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2019-nCoV基因组之间的单核苷酸多态性分析及其对密码子使用的影响

COVID-19的蔓延是全球关注的焦点，已经给整个人类健康造成了巨大损失。全球研究人员一直在努力制定应对这种可怕疾病的策略。专注于遗传变异性的研究有助于设计有效的药物和疫苗。考虑到这一点，本研究需要有关在全球108个SARS CoV-2基因组中检测到的全基因组突变的信息。我们确定了一些高变区位于orf1ab，穗和核衣壳基因。这些核苷酸多态性证明了它们对密码子使用以及氨基酸使用模式的影响。总而言之，本研究提供了宝贵的信息，这些信息将有助于正在进行的有关2019-nCoV疫苗开发的研究。