Inflammasome-induced neuroinflammation is a major pathogenic mechanism underlying the degeneration of nigral dopaminergic neurons in Parkinson’s disease (PD). Baicalein is a flavonoid isolated from the traditional Chinese medicinal herbal Scutellaria baicalensis Georgi with known anti-inflammatory and neuroprotective efficacy in models of neurodegenerative diseases, including PD. However, its effects on inflammasome-induced neuroinflammation during PD remain unclear.

中文翻译：

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在 MPTP 诱导的帕金森病小鼠模型中，黄芩素通过抑制 NLRP3/caspase-1/GSDMD 通路来减轻神经炎症。


炎症小体诱导的神经炎症是帕金森病（PD）黑质多巴胺能神经元变性的主要致病机制。黄芩素是从传统中药黄芩中分离出来的黄酮类化合物，在神经退行性疾病（包括帕金森病）模型中具有抗炎和神经保护功效。然而，其对帕金森病期间炎症小体诱导的神经炎症的影响仍不清楚。