The human body is made up of hundreds—perhaps thousands—of cell types and states, most of which are currently inaccessible genetically. Intersectional genetic approaches can increase the number of genetically accessible cells, but the scope and safety of these approaches have not been systematically assessed. A typical intersectional method acts like an “AND" logic gate by converting the input of 2 or more active, yet unspecific, regulatory elements (REs) into a single cell type specific synthetic output.

中文翻译：

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人类的交叉遗传学景观。

人体由成百上千种细胞类型和状态组成，其中大部分目前无法通过遗传获得。交叉遗传方法可以增加遗传可及细胞的数量，但这些方法的范围和安全性尚未得到系统评估。典型的交叉方法就像一个“与”逻辑门，通过将 2 个或更多活性但非特异性调节元件 (RE) 的输入转换为单个细胞类型特定的合成输出。