The human body is made up of hundreds—perhaps thousands—of cell types and states, most of which are currently inaccessible genetically. Intersectional genetic approaches can increase the number of genetically accessible cells, but the scope and safety of these approaches have not been systematically assessed. A typical intersectional method acts like an “AND" logic gate by converting the input of 2 or more active, yet unspecific, regulatory elements (REs) into a single cell type specific synthetic output.

中文翻译：

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人类的交叉遗传学景观。


人体由数百种甚至数千种细胞类型和状态组成，其中大多数目前无法从基因角度获得。交叉遗传方法可以增加可遗传细胞的数量，但这些方法的范围和安全性尚未得到系统评估。典型的交叉方法就像“AND”逻辑门一样，通过将 2 个或更多活跃但非特异性的调节元件 (RE) 的输入转换为单细胞类型特异性的合成输出。