Three new compounds named tanshinoic acid A (1), tanshinoic acid B (2), and tanshinoic acid C (3) were isolated from the rhizomes of Salvia miltiorrhiza, together with two known compounds methyl salvianolate A (4) and methyl salvianolate C (5). Their structures were determined on the basis of spectroscopic data (UV, IR, HRESIMS, 1 D and 2 D NMR). The in vitro assay indicated that 4 and 5 could improve the survived rate of cells on oxygen glucose deprivation (OGD) induced neurons damage model and glutamate-induced neurons damage model at a concentration of 10 μM.

中文翻译：

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丹参根状茎中的三种11,12-山高丹参酮衍生物。

从丹参的根茎中分离出三种新的化合物-丹参酸A（1），丹参酸B（2）和丹参酸C（3），以及两种已知的化合物丹酚甲酸甲酯A（4）和丹酚甲酸甲酯C（（5）。根据光谱数据（UV，IR，HRESIMS，1 D和2 D NMR）确定其结构。在体外测定法表明，4和5可以以10:1的浓度提高诱导的神经元损伤模型和谷氨酸诱导的神经元损伤模型上氧葡萄糖剥夺细胞（OGD）的存活率 μ M.