Abstract

We herein describe a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanides, and H₂O to access alkyl amides. Bench-stable NiCl₂(dppp) is competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process is proposed based on preliminary experiments and previous literature.

中文翻译：

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镍催化的卤代烷，异氰酸酯和H2O的多组分偶联反应：一种获取烷基酰胺的简便方法

摘要

我们在本文中描述了烷基卤，异氰酸酯和H ₂ O的Ni催化的多组分偶联反应，以得到烷基酰胺。稳定的NiCl ₂（dppp）能够在温和的反应条件下引发这种转变，从而使操作简便并增加实用价值。底物范围的研究表明，该方案对伯烷基卤和仲烷基卤具有广泛的官能团耐受性和通用性。基于初步实验和先前文献，提出了通过SET过程的合理的催化循环。