A method for the synthesis of iodomethyl-substituted five-membered sultams has been developed. The sultams were synthesized by intramolecular iodoamination of alkenyl sulfamides. The method allows synthesis of N- and C-substituted sultams. NH-Sultams were prepared by acidic cleavage of the corresponding tert-butyl sultams that are readily available. Varying the length of alkenyl substituent at sulfamide it was shown that only five- and six-membered sultams could be prepared by this method. Neither four- nor seven-membered sultams were detected. The simple practical procedure and available starting materials make the variously substituted sultams readily available.

中文翻译：

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3-碘甲基磺胺的合成

已开发出一种合成碘甲基取代的五元 sultams 的方法。磺胺是通过链烯基磺酰胺的分子内碘胺化合成的。该方法允许合成 N 和 C 取代的 sultam。NH-Sultams 是通过酸裂解相应的叔丁基 sultams 来制备的。改变磺酰胺中链烯基取代基的长度，表明该方法只能制备五元和六元磺胺。没有检测到四人或七人的 sultam。简单实用的程序和可用的起始材料使各种取代的舒坦很容易获得。