C1orf109L binding DHX9 promotes DNA damage depended on the R‐loop accumulation and enhances camptothecin chemosensitivity,Cell Proliferation

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C1orf109L binding DHX9 promotes DNA damage depended on the R‐loop accumulation and enhances camptothecin chemosensitivity
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-08-06 , DOI: 10.1111/cpr.12875
Peng Dou ₁ , Yiqun Li ₁ , Haoxiu Sun ₁ , Wanqiu Xie ₁ , Xiaoqing Zhang ₁ , Xiaohan Zhang ₁ , Dandan Zhang ₁ , Shupei Qiao ₁ , Yanpeng Ci ₁ , Huan Nie ₁ , Fang Han ₁ , Yu Li ₁

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R‐loop is a three‐stranded nucleic acid structure of RNA/DNA hybrid, which occurs naturally during transcription, and more R‐loop accumulation can trigger serious DNA damage. There has been increasing attention to the issue of R‐loop accumulation acted as a target for cancer therapy. However, the regulation of R‐loop‐associated proteins is poorly explored.

中文翻译：

C1orf109L结合DHX9促进依赖于R环积累的DNA损伤并增强喜树碱化学敏感性

R-loop 是 RNA/DNA 杂合体的三链核酸结构，在转录过程中自然发生，更多的 R-loop 积累会引发严重的 DNA 损伤。R-loop 积累作为癌症治疗靶点的问题越来越受到关注。然而，对 R 环相关蛋白的调控研究很少。

更新日期：2020-08-06

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