Nintedanib, an oral, triple angiokinase inhibitor is used alongside docetaxel in the management of locally recurrent non‐small cell lung cancer and idiopathic pulmonary fibrosis. The present study deals with the identification and characterization of in vitro and in vivo stable and reactive (if any) metabolites of nintedanib and sheds light on some novel metabolites of the drug, which were not reported previously.

中文翻译：

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通过高效液相色谱四极杆飞行时间串联质谱联用计算机进行毒理学评估，鉴定和鉴定了新达尼布的新代谢产物。

Nintedanib是一种口服三重血管激酶抑制剂，与多西他赛一起用于治疗局部复发的非小细胞肺癌和特发性肺纤维化。本研究致力于鉴定和表征nintedanib的体外和体内稳定和反应性（如果有的话）代谢产物，并阐明了该药物的一些新型代谢产物，以前没有报道。