Rapid single scan ramped hybrid-encoding for bicomponent T2* mapping in a human knee joint: A feasibility study.,NMR in Biomedicine

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Rapid single scan ramped hybrid-encoding for bicomponent T2* mapping in a human knee joint: A feasibility study.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-08-05 , DOI: 10.1002/nbm.4391
Hyungseok Jang ₁ , Alan B McMillan ₂ , Yajun Ma ₁ , Saeed Jerban ₁ , Eric Y Chang _{1,

3} , Jiang Du ₁ , Richard Kijowski ₂

Affiliation

The purpose of this study is to determine the feasibility of using a single scan ramped hybrid‐encoding (RHE) method for rapid bicomponent T2* analysis of the human knee joint. The proposed method utilizes RHE to acquire ultrashort echo time (UTE) and subsequent gradient echo images at 16 different echo times ranging between 40 μs and 30 ms in a single scan. In the proposed RHE technique, UTE imaging was followed by acquisition of 14 gradient recalled echo images, where an additional UTE image was obtained within the first readout by oversampling single point imaging (SPI) encoding. The single scan RHE method with a 9‐minute scan time was performed on human cadaveric knee joints from six donors and in vivo knee joints from four healthy volunteers at 3 T. A bicomponent signal model was used to characterize the short T2* and long T2* water components. Mean bicomponent T2* parameters for patellar tendon, anterior cruciate ligament (ACL), posterior cruciate ligament (PCL) and meniscus were calculated. In the experimental results, the RHE technique provided bicomponent T2* parameter estimations of tendon, ACL, PCL and meniscus, which were similar to previously reported values in the literature. In conclusion, the proposed single scan RHE technique provides rapid bicomponent T2* analysis of the human knee joint with a total scan time of less than 9 minutes.

中文翻译：

用于人类膝关节双分量 T2* 映射的快速单次扫描斜坡混合编码：一项可行性研究。

本研究的目的是确定使用单扫描斜坡混合编码 (RHE) 方法对人类膝关节进行快速双分量 T2* 分析的可行性。所提出的方法利用 RHE 在单次扫描中以 40 μs 和 30 ms 之间的 16 个不同回波时间获取超短回波时间 (UTE) 和后续梯度回波图像。在提议的 RHE 技术中，UTE 成像之后是采集 14 个梯度回波图像，其中通过过采样单点成像 (SPI) 编码在第一次读出中获得了额外的 UTE 图像。以 9 分钟扫描时间对来自六名捐赠者的人体膝关节和来自四名健康志愿者的体内膝关节进行了 3 T 的单次扫描 RHE 方法。双分量信号模型用于表征短 T2* 和长 T2* 水分量。计算了髌腱、前交叉韧带 (ACL)、后交叉韧带 (PCL) 和半月板的平均双组分 T2* 参数。在实验结果中，RHE 技术提供了肌腱、ACL、PCL 和半月板的双分量 T2* 参数估计，这与文献中先前报道的值相似。总之，所提出的单次扫描 RHE 技术提供了对人体膝关节的快速双分量 T2* 分析，总扫描时间不到 9 分钟。RHE 技术提供了肌腱、ACL、PCL 和半月板的双分量 T2* 参数估计，这与文献中先前报道的值相似。总之，所提出的单次扫描 RHE 技术提供了对人体膝关节的快速双分量 T2* 分析，总扫描时间不到 9 分钟。RHE 技术提供了肌腱、ACL、PCL 和半月板的双分量 T2* 参数估计，这与文献中先前报道的值相似。总之，所提出的单次扫描 RHE 技术提供了对人体膝关节的快速双分量 T2* 分析，总扫描时间不到 9 分钟。

更新日期：2020-10-05

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