Mussel-Inspired Polydopamine: The Bridge for Targeting Drug Delivery System and Synergistic Cancer Treatment.,Macromolecular Bioscience

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Mussel-Inspired Polydopamine: The Bridge for Targeting Drug Delivery System and Synergistic Cancer Treatment.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-08-06 , DOI: 10.1002/mabi.202000222
Wenyan Wang ₁ , Zhuo Tang ₁ , Yi Zhang ₁ , Qiuxu Wang ₂ , Zhigang Liang ₂ , Xiaowei Zeng ₁

Affiliation

Polydopamine (PDA), a mussel‐inspired molecule, has been recognized as attractive in cancer therapy due to a number of inherent advantages, such as good biocompatibility, outstanding drug‐loading capacity, degradability, superior photothermal conversion efficiency, and low tissue toxicity. Furthermore, due to its strong adhesive property, PDA is able to functionalize various nanomaterials, facilitating the construction of a PDA‐based multifunctional platform for targeted or synergistic therapy. Herein, recent PDA research, including targeted drug delivery, single‐mode therapy, and diverse synergistic therapies against cancer, are summarized and discussed. For synergistic therapy, advanced developments are highlighted, such as photothermal/radiotherapy, chemo−/photothermal/gene therapy, photothermal/immune therapy, and photothermal/photodynamic/immune therapy. Finally, the challenges and promise of PDA for biomedical applications in the future are discussed.

中文翻译：

受贻贝启发的聚多巴胺：靶向给药系统和协同癌症治疗的桥梁。

聚多巴胺（PDA）是一种受贻贝启发的分子，由于具有许多固有优势，例如良好的生物相容性、出色的载药量、可降解性、优异的光热转换效率和低组织毒性，已被公认为在癌症治疗中具有吸引力。此外，由于其强大的粘附性，PDA 能够使各种纳米材料功能化，有助于构建基于 PDA 的多功能平台，用于靶向或协同治疗。在此，总结和讨论了最近的 PDA 研究，包括靶向药物递送、单模式治疗和多种抗癌协同治疗。对于协同治疗，突出了先进的发展，例如光热/放射治疗、化学-/光热/基因治疗、光热/免疫治疗、和光热/光动力/免疫疗法。最后，讨论了PDA在未来生物医学应用中的挑战和前景。

更新日期：2020-10-12

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