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Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge.
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-08-06 , DOI: 10.1111/gbb.12691 Ying Kong 1 , Qian Wang 1 , Ding-Yu Wu 1 , Jian Hu 1 , Wen-Si Zang 1 , Xiao-Wen Li 1 , Jian-Ming Yang 1 , Tian-Ming Gao 1
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-08-06 , DOI: 10.1111/gbb.12691 Ying Kong 1 , Qian Wang 1 , Ding-Yu Wu 1 , Jian Hu 1 , Wen-Si Zang 1 , Xiao-Wen Li 1 , Jian-Ming Yang 1 , Tian-Ming Gao 1
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P2X2 and P2X3 receptors are widely expressed in both the peripheral nervous system and the central nervous system and have been proven to participate in different peripheral sensory functions, but there are few studies on the involvement of P2X2 and P2X3 receptors in animal behaviors. Here we used P2X2 and P2X3 knockout mice to address this issue. P2X2 knockout mice showed normal motor function, exploratory behavior, anxiety‐like behaviors, learning and memory behaviors and passive coping response to behavioral challenge. Nevertheless, the effect of ATP infusion in the medial prefrontal cortex (mPFC) on the passive coping response was blocked by P2X2 but not P2X3 receptor deletion. Additionally, no deficits in a wide variety of behavioral tests were observed in P2X3 knockout mice. These findings demonstrate a role of P2X2 receptor in the mPFC in adenosine‐5′‐triphosphate modulation of the passive coping response to behavioral challenge and show that the P2X2/P2X3 receptor is dispensable for behaviors.
中文翻译：
P2X2 受体在内侧前额叶皮层参与对行为挑战的被动应对反应的 ATP 调节。
P2X2和P2X3受体在外周神经系统和中枢神经系统均广泛表达，已被证明参与不同的外周感觉功能，但关于P2X2和P2X3受体参与动物行为的研究较少。在这里，我们使用 P2X2 和 P2X3 基因敲除小鼠来解决这个问题。P2X2 基因敲除小鼠表现出正常的运动功能、探索行为、焦虑样行为、学习和记忆行为以及对行为挑战的被动应对反应。然而，内侧前额叶皮层 (mPFC) 中 ATP 输注对被动应对反应的影响被 P2X2 而不是 P2X3 受体缺失阻断。此外，在 P2X3 基因敲除小鼠中没有观察到各种行为测试的缺陷。
更新日期：2020-08-06
中文翻译：
P2X2 受体在内侧前额叶皮层参与对行为挑战的被动应对反应的 ATP 调节。
P2X2和P2X3受体在外周神经系统和中枢神经系统均广泛表达，已被证明参与不同的外周感觉功能，但关于P2X2和P2X3受体参与动物行为的研究较少。在这里，我们使用 P2X2 和 P2X3 基因敲除小鼠来解决这个问题。P2X2 基因敲除小鼠表现出正常的运动功能、探索行为、焦虑样行为、学习和记忆行为以及对行为挑战的被动应对反应。然而，内侧前额叶皮层 (mPFC) 中 ATP 输注对被动应对反应的影响被 P2X2 而不是 P2X3 受体缺失阻断。此外，在 P2X3 基因敲除小鼠中没有观察到各种行为测试的缺陷。
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