Acidity and Glutathione Dual-Responsive Polydopamine-Coated Organic-Inorganic Hybrid Hollow Mesoporous Silica Nanoparticles for Controlled Drug Delivery.,ChemMedChem

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Acidity and Glutathione Dual-Responsive Polydopamine-Coated Organic-Inorganic Hybrid Hollow Mesoporous Silica Nanoparticles for Controlled Drug Delivery.
ChemMedChem ( IF 3.6 ) Pub Date : 2020-08-06 , DOI: 10.1002/cmdc.202000263
Qi Chen _{1,

2} , Yunna Chen _{1,

2,

3} , Wenjing Zhang _{1,

2,

3} , Qianqian Huang _{1,

2,

3} , Mengru Hu _{1,

2,

3} , Daiyin Peng _{1,

2} , Can Peng _{1,

2,

3,

4} , Lei Wang _{1,

2,

3,

4} , Weidong Chen _{1,

2,

3,

4}

Affiliation

Controversial biodegradability and nonspecific pre‐drug leakage are major limitations for inorganic nanoparticles in cancer treatment. To solve these problems, we developed organic‐inorganic hybridized hollow mesoporous silica nanoparticles with polydopamine modifications on the surface to simultaneously achieve enhanced biodegradability and controllable drug release. The morphology and chemical structure of the nanoparticles were characterized by TEM, N₂ adsorption‐desorption isotherms, TEM‐mapping and XPS. Moreover, the release behavior of nanoparticles under various pH conditions and the degradation behavior in the presence of GSH were evaluated. With effective controlled release, HMONs‐PTX@PDA were shown to significantly inhibit cancer cell proliferation and achieve antitumor effects in vivo through dual‐response release in the tumor microenvironment. Overall, this nanoplatform has significant potential to achieve tumor microenvironment‐responsive degradation and release to enhance tumor accumulation, which is very promising for cancer treatment.

中文翻译：

酸度和谷胱甘肽双响应聚多巴胺包被的有机-无机杂化中空介孔二氧化硅纳米颗粒，用于控制药物递送。

有争议的生物降解性和非特异性药物前泄漏是无机纳米粒子在癌症治疗中的主要限制。为了解决这些问题，我们开发了表面具有聚多巴胺修饰的有机-无机杂化中空介孔二氧化硅纳米粒子，以同时实现增强的生物降解性和可控的药物释放。纳米粒子的形貌和化学结构通过TEM、N ₂吸附-解吸等温线、TEM-mapping 和 XPS。此外，还评估了纳米颗粒在各种 pH 条件下的释放行为和谷胱甘肽存在下的降解行为。通过有效的控释，HMONs-PTX@PDA被证明可以通过在肿瘤微环境中的双重反应释放来显着抑制癌细胞增殖并在体内实现抗肿瘤作用。总体而言，该纳米平台具有实现肿瘤微环境响应性降解和释放以增强肿瘤积累的巨大潜力，这对于癌症治疗非常有前景。

更新日期：2020-08-06

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