Introduction

Many symptoms of COVID‐19, such as stroke, anosmia and dysregulation of breathing are considered to be directly or partly attributable to neuropathological processes (4). Furthermore, severe radiologically verified manifestations, such as acute hemorrhagic necrotizing encephalitis (AHLE) and acute disseminated encephalomyelitis (ADEM) have been reported (5). Here, we present neuropathological findings of a series of autopsies performed at the Helsinki University Hospital April 14 through May 18, 2020, comprising four patients who had tested positive for SARS‐CoV2 with RT‐PCR prior to death. A full neuropathological examination was performed on two patients, while two had extended neuropathological sampling of at least nine CNS areas including olfactory bulbs/tracts during autopsy. Olfactory mucosa was sampled from all four and carotid bodies from three patients.

中文翻译：

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四名尸检的 COVID-19 患者的神经病理学特征。

介绍

COVID-19 的许多症状，例如中风、嗅觉障碍和呼吸失调，被认为直接或部分归因于神经病理过程 ( 4 )。此外，已经报道了严重的放射学证实的表现，例如急性出血性坏死性脑炎（AHLE）和急性播散性脑脊髓炎（ADEM）（5）。在这里，我们展示了 2020 年 4 月 14 日至 5 月 18 日在赫尔辛基大学医院进行的一系列尸检的神经病理学结果，其中包括四名在死亡前通过 RT-PCR 检测出 SARS-CoV2 阳性的患者。对两名患者进行了全面的神经病理学检查，而两名患者在尸检期间对至少九个 CNS 区域（包括嗅球/束）进行了扩展的神经病理学取样。对所有四名患者的嗅粘膜和来自三名患者的颈动脉体进行采样。