Potential proton pump inhibitor–related adverse effects,Annals of the New York Academy of Sciences

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Potential proton pump inhibitor–related adverse effects
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2020-08-06 , DOI: 10.1111/nyas.14428
Issac E Perry ₁ , Irene Sonu ₂ , Carmelo Scarpignato _{3,

4} , Junichi Akiyama ₅ , Michio Hongo _{6,

7} , Kenneth J Vega ₁

Affiliation

Proton pump inhibitors (PPIs) are one of the most common medications taken by patients worldwide. PPIs are used to treat acid‐related disorders, including gastroesophageal reflux disease, peptic ulcer disease, Helicobacter pylori infection, and nonsteroidal anti‐inflammatory drug/stress ulceration. For some of these diseases, long‐term treatment is necessary. With such prolonged use, concern and investigation into potential adverse effects has increased. In addition, data are available regarding potential anticancer effects of PPIs, especially regarding solid tumors. The aim of this review is to assess the literature on PPIs with regard to common concerns, such as drug–drug interactions, the intestinal microbiome, dementia and central nervous system disease, and osteoporosis, as well as to highlight potential negative and positive impacts of the drug in cancer.

中文翻译：

潜在的质子泵抑制剂相关的不良反应

质子泵抑制剂 (PPI) 是全世界患者最常用的药物之一。PPI 用于治疗酸相关疾病，包括胃食管反流病、消化性溃疡病、幽门螺杆菌感染和非甾体抗炎药/应激性溃疡。对于其中一些疾病，需要长期治疗。随着如此长时间的使用，对潜在不良影响的关注和调查有所增加。此外，还有关于 PPI 潜在抗癌作用的数据，尤其是实体瘤。本综述的目的是评估关于 PPI 的文献，这些文献涉及常见问题，例如药物相互作用、肠道微生物组、痴呆和中枢神经系统疾病以及骨质疏松症，

更新日期：2020-08-06

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