Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics.,Advanced Materials

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Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics.
Advanced Materials ( IF 27.4 ) Pub Date : 2020-08-06 , DOI: 10.1002/adma.202003382
Jiachang Huang _{1,

2,

3} , Benzhao He ₃ , Zhijun Zhang _{1,

2} , Youmei Li _{1,

2} , Miaomiao Kang _{1,

2} , Yuanwei Wang _{1,

2} , Kai Li ₄ , Dong Wang ₁ , Ben Zhong Tang ₃

Affiliation

Inspired by the respective advantages of aggregation‐induced emission (AIE)‐active photosensitizers and black phosphorus nanomaterials in cancer treatment, the facile construction of novel AIE photosensitizers married to 2D black phosphorus nanosheets and their application for multimodal theranostics are demonstrated. The developed nanomaterial simultaneously possesses distinctive properties and multiple functions including excellent stability, good biocompatibility, intensive fluorescence emission in the NIR region, high‐performance reactive oxygen species generation, good photothermal conversion efficiency, outstanding cellular uptake, and effective accumulation at the tumor site. Both in vitro and in vivo evaluation show that the presented nanotheranostic system is an excellent candidate for NIR fluorescence–photothermal dual imaging‐guided synergistic photodynamic–photothermal therapies. This study thus not only extends the applications scope of AIE and black phosphorus materials, but also offers useful insights into designing a new generation of cancer theranostic protocol for potential clinical applications.

中文翻译：

聚集诱导的发光源与二维黑色磷纳米片相结合，以实现高效的多峰治疗学。

受聚集诱导发射（AIE）活性光敏剂和黑磷纳米材料在癌症治疗中各自优点的启发，证明了与2D黑磷纳米片相结合的新型AIE光敏剂的简便构建及其在多峰理论上的应用。所开发的纳米材料同时具有独特的特性和多种功能，包括出色的稳定性，良好的生物相容性，在近红外区域的密集荧光发射，高性能的活性氧生成，良好的光热转化效率，出色的细胞吸收以及在肿瘤部位的有效积累。体外和体内评估均表明，所提出的纳米热力学系统是近红外荧光光热双成像引导协同光动力光热疗法的极佳候选者。因此，这项研究不仅扩展了AIE和黑磷材料的应用范围，而且还为设计用于潜在临床应用的新一代癌症治疗方法提供了有用的见识。

更新日期：2020-09-15

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